Personal site of Ph.D Roman G. Myazin

Chronic Viral Hepatitis C (second example)

Patient S-aya N.S., 38, visited gastroenterologist – hepatologist on July, 26, 2008 with complaints of aching pains in the right hypochondrium, the decrease of efficiency.

From anamnesis: two years ago during the casual preventive examination of the patient HCV antibodies were detected. A month ago the patient felt worse and began to take as a self-care the decoction of silibum marianum and other hepatoprotectors with an insignificant effect.

Objectively: dermal integuments and sclera are of usual staining, the lower edge of the right lobe of  liver is along  the right costal margin edge, it is soft,  the palpation is painless. The spleen isn’t palpable.

According to the results of the abdominal cavity ultrasound investigation: the liver tissue is of usual echogenicity, homogeneous. The anteroposterior size of the right lobe of liver is 12,2 cm, of the left lobe of liver – 6,4 cm, of the caudate lobe of liver – 3,8 cm.

Common blood analysis: Er – 4,2´1012, Hb - 130 g/l, colour index – 0,93, Tr - 340´109, Le - 4,9´109, b -0, e - 1, band neutrophils - 4, s – 49, l – 32, m - 5. ESR – 8 mm/h. Blood clotting time – 4 min 20 sec. Blood glucose – 4,4 mmol/l. Whole protein – 89 g/l, albumins – 48 %, a1-globulins – 4 %, a2 – globulins – 12 %, b-globulins – 17 %, g-globulins – 18 %, A/G coefficient -0,96.

Clinical urine analysis: light-yellow, transparent, reaction – acid, relative density – 1016, glucose – not detected, protein – not detected, Le – 2-4 within eyesight, Er – not detected, plano epithelium cells – a small number, cylinders –not detected.

Biochemical tests: MDA – 12,8 mkmol/l, DC – 1,4 u., Cat – 14,6 mkmol/ml/min, SOD – 1,2 conv.u/ml, GP – 3,0 mkmol/ml/min, SU – 0,2 u., SG -0,1 u., CPl – 36,3 mg%, NAG – 14,8 nmol/ml/min, total bilirubin – 22,0 mkmol/l, thymol test - 5,5 u., ALT – 1,0  mkkat/l, AST – 0,46 mkkat/l.

To make the diagnosis of liver disease and its activity more exact, the complex investigation of the presence of hepatitis C virus in the blood serum of the patient by the method of Polimerase Chain Reaction (PCR) were made.

Virologic tests: HCV-infection, genotype 1b; HCV RNA was detected by the method of PCR. While testing the amount of virus viral load level was 6,91´105 MU/l.

For the purpose of detoxicant and antiviral treatment the patient underwent according to the scheme the monotherapy course of 10 intravenous drip infusions of Natrii Hypochloriti into the cubital vein with the speed of 30 drips per minute in the concentration of 300 mg/l of the fresh-made solution as 200 ml injections in a day. The patient underwent the procedures successfully.

1 month after the finishing of the course of treatment all above-named investigations were made once again.  It was detected the normalization of LPO indices, liver-specific enzymes and standard liver tests. It was observed a significant increase of AOP enzymes: MDA – 6,25 mkmol/l, DC – 0,95 u., Cat – 24,0 mkmol/ml/min, SOD – 2,2 conv. u./ml, GP – 4,3 mkmol/ml/min, SU - 0 u., SG – 0 u., CPl – 34,7 mg%, NAG – 11,1 nmol/ml/min, total bilirubin – 14,0 mkmol/l, thymol test -3,5 u., ALT – 0,3 mkkat/l, AST – 0,22 mkkat/l.

At the end of the course of treatment the patient subjectively felt better and didn’t have any aching pains in the right hypochondrium, the appetite improved, the efficiency of the patient increased. The patient didn’t take any other antiviral preparations which can influence HCV virus.

The recurring virologic testing after the course of Natrii Hypochloriti treatment showed:  HCV RNA was detected by the method of PCR. While testing the amount of virus viral load level decreased in 15 times and became 4,74´104 MU/l.

It is being planned to carry out in the nearest future a recurring course of Natrii Hypochloriti treatment to improve the virologic dynamics and to achieve the complete recovery of the patient from viral hepatitis С.

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